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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1867
http://purl.obolibrary.org/obo/NCIT_C1867
|
|---|---|
| Preferred Name | Ortataxel |
| Definitions |
A semisynthetic, second-generation taxane derivative with potential antineoplastic activity. Ortataxel binds to and stabilizes tubulin molecules, thereby interfering with the dynamics of microtubule assembly/disassembly. This results in the inhibition of cell division and cellular proliferation. As it represents a poor substrate for P-glycoprotein (P-gp), multi-drug resistance protein (MRP-1) and breast cancer resistance protein (BCRP) mediated efflux, ortataxel modulates multi-drug resistance mechanisms and may be useful for treating multi-drug resistant tumors that express Pgp, MRP-1 and BCRP.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A semisynthetic, second-generation taxane derivative with potential antineoplastic activity. Ortataxel binds to and stabilizes tubulin molecules, thereby interfering with the dynamics of microtubule assembly/disassembly. This results in the inhibition of cell division and cellular proliferation. As it represents a poor substrate for P-glycoprotein (P-gp), multi-drug resistance protein (MRP-1) and breast cancer resistance protein (BCRP) mediated efflux, ortataxel modulates multi-drug resistance mechanisms and may be useful for treating multi-drug resistant tumors that express Pgp, MRP-1 and BCRP. |
|---|---|
| label | Ortataxel
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| prefLabel | Ortataxel
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| Legacy Concept Name | Orataxel
|
| in_subset | |
| Preferred_Name | Ortataxel
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| Is_Value_For_GDC_Property | |
| Maps_To | Ortataxel
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| PDQ_Open_Trial_Search_ID | 38635
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| UMLS_CUI | C1527103
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| FDA_UNII_Code | 8H61Y4E29N
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| prefixIRI | NCIT:C1867
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| NCI_Drug_Dictionary_ID | 38635
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| Contributing_Source | FDA
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| subClassOf | |
| code | C1867
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| type | |
| ALT_DEFINITION | A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called taxanes.
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| PDQ_Closed_Trial_Search_ID | 38635
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| CAS_Registry | 186348-23-2
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