Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C1865
http://purl.obolibrary.org/obo/NCIT_C1865
Preferred Name

Ribozyme RPI.4610
Definitions
A nuclease-stabilized synthetic ribozyme (ribonucleic acid enzyme) with potential anti-angiogenesis activity. Ribozyme RPI.4610 specifically recognizes the mRNA for FLT1 (vascular endothelial growth factor receptor 1; VEGFR1), and hydrolyzes the mRNA, thereby preventing VEGFR1 proteins from being made. This may prevent VEGF-stimulated angiogenesis in cancerous tissue and metastasis.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A nuclease-stabilized synthetic ribozyme (ribonucleic acid enzyme) with potential anti-angiogenesis activity. Ribozyme RPI.4610 specifically recognizes the mRNA for FLT1 (vascular endothelial growth factor receptor 1; VEGFR1), and hydrolyzes the mRNA, thereby preventing VEGFR1 proteins from being made. This may prevent VEGF-stimulated angiogenesis in cancerous tissue and metastasis.
prefLabel
Ribozyme RPI.4610
label
Ribozyme RPI.4610
PDQ_Closed_Trial_Search_ID
38358
code
C1865
prefixIRI
NCIT:C1865
in_subset
Preferred_Name
Ribozyme RPI.4610
Maps_To
Ribozyme RPI.4610
NCI_Drug_Dictionary_ID
38358
Legacy Concept Name
Angiozyme
type
ALT_DEFINITION
A substance being studied in the treatment of cancer. RPI.4610 is a special type of RNA made in the laboratory. It stops a protein called vascular endothelial growth factor receptor (VEGFR) from being made. This may prevent the growth of new blood vessels that tumors need to grow. It is a type of angiogenesis inhibitor and a type of ribozyme.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
38358
Semantic_Type
Amino Acid, Peptide, or Protein
Pharmacologic Substance
UMLS_CUI
C0908892
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