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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1854
http://purl.obolibrary.org/obo/NCIT_C1854
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|---|---|
| Preferred Name | Pegfilgrastim |
| Definitions |
A long-acting pegylated form of a recombinant therapeutic agent which is chemically identical to or similar to an endogenous human granulocyte colony-stimulating factor (G-CSF). Produced endogenously by monocytes, fibroblasts, and endothelial cells, G-CSF binds to and activates specific cell surface receptors, stimulating neutrophil progenitor proliferation and differentiation and selected neutrophil functions. Conjugation of the cytokine with a branched polyethylene glycol molecule (pegylation) significantly increases its therapeutic half-life. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A long-acting pegylated form of a recombinant therapeutic agent which is chemically identical to or similar to an endogenous human granulocyte colony-stimulating factor (G-CSF). Produced endogenously by monocytes, fibroblasts, and endothelial cells, G-CSF binds to and activates specific cell surface receptors, stimulating neutrophil progenitor proliferation and differentiation and selected neutrophil functions. Conjugation of the cytokine with a branched polyethylene glycol molecule (pegylation) significantly increases its therapeutic half-life. (NCI04) |
|---|---|
| prefLabel | Pegfilgrastim
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| label | Pegfilgrastim
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| PDQ_Closed_Trial_Search_ID | 37807
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| code | C1854
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| prefixIRI | NCIT:C1854
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| in_subset |
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| Display_Name | Pegfilgrastim
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| Preferred_Name | Pegfilgrastim
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| FDA_UNII_Code | 3A58010674
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| Contributing_Source |
CTRP
FDA
PCDC
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| Chemical_Formula | C3H8NO(C2H4O)n
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| Maps_To | Pegfilgrastim
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| CAS_Registry | 208265-92-3
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| NSC Number | 725961
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| NCI_Drug_Dictionary_ID | 37807
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| Legacy Concept Name | Pegfilgrastim
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| type | |
| ALT_DEFINITION | A drug used to increase numbers of white blood cells in patients who are receiving chemotherapy. It is a type of colony-stimulating factor.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 37807
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| Accepted_Therapeutic_Use_For | Chemotherapy-induced neutropenia
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| UMLS_CUI | C1136535
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