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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1848
http://purl.obolibrary.org/obo/NCIT_C1848
|
|---|---|
| Preferred Name | Suramin Sodium |
| Definitions |
A sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factor-beta (TGF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. This agent also inhibits vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis.
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factor-beta (TGF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. This agent also inhibits vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis. |
|---|---|
| prefLabel | Suramin Sodium
|
| label | Suramin Sodium
|
| PDQ_Closed_Trial_Search_ID | 40052
|
| code | C1848
|
| Has_Target | |
| prefixIRI | NCIT:C1848
|
| in_subset | |
| Preferred_Name | Suramin Sodium
|
| FDA_UNII_Code | 89521262IH
|
| Contributing_Source | FDA
|
| Chemical_Formula | C51H34N6O23S6.6Na
|
| Maps_To | Suramin Sodium
|
| CAS_Registry | 129-46-4
|
| NSC Number | 34936
|
| NCI_Drug_Dictionary_ID | 40052
|
| Legacy Concept Name | Suramin_Sodium
|
| Has_Free_Acid_Or_Base_Form | |
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 40052
|
| Accepted_Therapeutic_Use_For | African trypanosomiasis; onchocerciasis
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
|
| UMLS_CUI | C0813205
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