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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1843
http://purl.obolibrary.org/obo/NCIT_C1843
|
|---|---|
| Preferred Name | BMS-184476 |
| Definitions |
A 7-methylthiomethyl ether derivative of paclitaxel with antineoplastic activity. BMS-184476 binds to and stabilizes the resulting microtubules, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and apoptosis. (NCI)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A 7-methylthiomethyl ether derivative of paclitaxel with antineoplastic activity. BMS-184476 binds to and stabilizes the resulting microtubules, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and apoptosis. (NCI) |
|---|---|
| prefLabel | BMS-184476
|
| label | BMS-184476
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| PDQ_Closed_Trial_Search_ID | 43331
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| code | C1843
|
| prefixIRI | NCIT:C1843
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| in_subset | |
| Preferred_Name | BMS-184476
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| FDA_UNII_Code | 3811W2NBZ8
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| Contributing_Source | FDA
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| Maps_To | BMS-184476
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| CAS_Registry | 160237-25-2
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| NCI_Drug_Dictionary_ID | 43331
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| Legacy Concept Name | BMS-184476
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| type | |
| ALT_DEFINITION | A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called mitotic inhibitors.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 43331
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0796479
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