Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1840
http://purl.obolibrary.org/obo/NCIT_C1840
|
|---|---|
| Preferred Name | Farnesyltransferase/Geranylgeranyltransferase Inhibitor L-778,123 |
| Definitions |
A benzonitrile derivative capable of inhibiting some prenyltransferases. L-778,123 is a dual inhibitor of farnesyl:protein and geranylgeranyl:protein transferases; both enzymes catalyze prenylation of oncoprotein KRAS, a prerequisite step in activation of KRAS in signal transduction pathway of apoptosis. Although this agent was developed in part as an anti-KRAS agent, L-778,123 failed in a Phase I trial to inhibit KRAS, which is associated with many types of solid tumors.
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A benzonitrile derivative capable of inhibiting some prenyltransferases. L-778,123 is a dual inhibitor of farnesyl:protein and geranylgeranyl:protein transferases; both enzymes catalyze prenylation of oncoprotein KRAS, a prerequisite step in activation of KRAS in signal transduction pathway of apoptosis. Although this agent was developed in part as an anti-KRAS agent, L-778,123 failed in a Phase I trial to inhibit KRAS, which is associated with many types of solid tumors. |
|---|---|
| prefLabel | Farnesyltransferase/Geranylgeranyltransferase Inhibitor L-778,123
|
| label | Farnesyltransferase/Geranylgeranyltransferase Inhibitor L-778,123
|
| PDQ_Closed_Trial_Search_ID | 43144
|
| code | C1840
|
| prefixIRI | NCIT:C1840
|
| in_subset | |
| Preferred_Name | Farnesyltransferase/Geranylgeranyltransferase Inhibitor L-778,123
|
| FDA_UNII_Code | 2A2059P49U
|
| Contributing_Source | FDA
|
| Maps_To | Farnesyltransferase/Geranylgeranyltransferase Inhibitor L-778,123
|
| CAS_Registry | 253863-00-2
|
| NCI_Drug_Dictionary_ID | 43144
|
| Legacy Concept Name | L-778_123
|
| type | |
| ALT_DEFINITION | An anticancer drug that belongs to the family of drugs called enzyme inhibitors. It may inhibit the transformation of normal cells into cancer cells.
|
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 43144
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
|
| UMLS_CUI | C0796327
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |