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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1835
http://purl.obolibrary.org/obo/NCIT_C1835
|
|---|---|
| Preferred Name | Batabulin Sodium |
| Definitions |
The sodium salt form of batabulin, a synthetic pentafluorophenylsulfonamide with potential antineoplastic activity. Batabulin covalently binds to and selectively modifies the beta 1, beta 2, beta 3, and beta 4 isotypes of beta tubulin at a conserved cysteine residue, resulting in disruption of microtubule polymerization, collapse of the cytoskeleton, an increase in chromosomal ploidy, cell cycle arrest, and tumor cell apoptosis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The sodium salt form of batabulin, a synthetic pentafluorophenylsulfonamide with potential antineoplastic activity. Batabulin covalently binds to and selectively modifies the beta 1, beta 2, beta 3, and beta 4 isotypes of beta tubulin at a conserved cysteine residue, resulting in disruption of microtubule polymerization, collapse of the cytoskeleton, an increase in chromosomal ploidy, cell cycle arrest, and tumor cell apoptosis. |
|---|---|
| prefLabel | Batabulin Sodium
|
| label | Batabulin Sodium
|
| PDQ_Closed_Trial_Search_ID | 43107
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| code | C1835
|
| prefixIRI | NCIT:C1835
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| in_subset | |
| Preferred_Name | Batabulin Sodium
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| FDA_UNII_Code | G04B77F772
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| Contributing_Source | FDA
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| Chemical_Formula | C13H6F6NO3S.Na
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| Maps_To | Batabulin Sodium
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| CAS_Registry | 195533-98-3
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| NCI_Drug_Dictionary_ID | 43107
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| Legacy Concept Name | T138067
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| Has_Free_Acid_Or_Base_Form | |
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 43107
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0767921
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| Delete | Subject | Author | Type | Created |
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