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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1831
http://purl.obolibrary.org/obo/NCIT_C1831
|
|---|---|
| Preferred Name | Semaxanib |
| Definitions |
A quinolone derivative with potential antineoplastic activity. Semaxanib reversibly inhibits ATP binding to the tyrosine kinase domain of vascular endothelial growth factor receptor 2 (VEGFR2), which may inhibit VEGF-stimulated endothelial cell migration and proliferation and reduce the tumor microvasculature. This agent also inhibits the phosphorylation of the stem cell factor receptor tyrosine kinase c-kit, often expressed in acute myelogenous leukemia cells.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A quinolone derivative with potential antineoplastic activity. Semaxanib reversibly inhibits ATP binding to the tyrosine kinase domain of vascular endothelial growth factor receptor 2 (VEGFR2), which may inhibit VEGF-stimulated endothelial cell migration and proliferation and reduce the tumor microvasculature. This agent also inhibits the phosphorylation of the stem cell factor receptor tyrosine kinase c-kit, often expressed in acute myelogenous leukemia cells. |
|---|---|
| prefLabel | Semaxanib
|
| label | Semaxanib
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| PDQ_Closed_Trial_Search_ID | 43310
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| code | C1831
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| Has_Target | |
| prefixIRI | NCIT:C1831
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| in_subset |
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| Display_Name | Semaxanib
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| Preferred_Name | Semaxanib
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| FDA_UNII_Code | 71IA9S35AJ
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C15H14N2O
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| Maps_To | Semaxanib
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| CAS_Registry | 194413-58-6
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| NSC Number | 696819
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| NCI_Drug_Dictionary_ID | 43310
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| Legacy Concept Name | Semaxanib
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| type | |
| ALT_DEFINITION | A substance that has been studied in the treatment of cancer. It belongs to the families of drugs called angiogenesis inhibitors and tyrosine kinase inhibitors.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 43310
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C1135174
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