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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1829
http://purl.obolibrary.org/obo/NCIT_C1829
|
|---|---|
| Preferred Name | Lonafarnib |
| Definitions |
A synthetic tricyclic derivative of carboxamide with antineoplastic properties. Lonarfanib binds to and inhibits farnesyl transferase, an enzyme involved in the post-translational modification and activation of Ras proteins. Ras proteins participate in numerous signalling pathways (proliferation, cytoskeletal organization), and play an important role in oncogenesis. Mutated ras proteins have been found in a wide range of human cancers. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic tricyclic derivative of carboxamide with antineoplastic properties. Lonarfanib binds to and inhibits farnesyl transferase, an enzyme involved in the post-translational modification and activation of Ras proteins. Ras proteins participate in numerous signalling pathways (proliferation, cytoskeletal organization), and play an important role in oncogenesis. Mutated ras proteins have been found in a wide range of human cancers. (NCI04) |
|---|---|
| prefLabel | Lonafarnib
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| label | Lonafarnib
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| PDQ_Closed_Trial_Search_ID | 43503
|
| code | C1829
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| Has_Target | |
| prefixIRI | NCIT:C1829
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| in_subset |
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| Display_Name | Lonafarnib
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| Preferred_Name | Lonafarnib
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| FDA_UNII_Code | IOW153004F
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C27H31Br2ClN4O2
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| Maps_To | Lonafarnib
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| CAS_Registry | 193275-84-2
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| NSC Number | 719467
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| NCI_Drug_Dictionary_ID | 43503
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| Legacy Concept Name | Lonafarnib
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| type | |
| ALT_DEFINITION | An anticancer drug that belongs to the family of drugs called enzyme inhibitors.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 43503
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C1257385
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| Delete | Subject | Author | Type | Created |
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