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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1820
http://purl.obolibrary.org/obo/NCIT_C1820
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|---|---|
| Preferred Name | Mitomycin |
| Definitions |
A methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. Bioreduced mitomycin C generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. Preferentially toxic to hypoxic cells, mitomycin C also inhibits RNA and protein synthesis at high concentrations. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. Bioreduced mitomycin C generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. Preferentially toxic to hypoxic cells, mitomycin C also inhibits RNA and protein synthesis at high concentrations. (NCI04) |
|---|---|
| prefLabel | Mitomycin
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| label | Mitomycin
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| CHEBI_ID | CHEBI:27504
|
| PDQ_Closed_Trial_Search_ID | 42674
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| code | C1820
|
| prefixIRI | NCIT:C1820
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| in_subset |
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| Display_Name | Mitomycin
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| Preferred_Name | Mitomycin
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| FDA_UNII_Code | 50SG953SK6
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C15H18N4O5
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| Maps_To | Mitomycin
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| CAS_Registry | 50-07-7
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| NSC Number | 26980
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| NCI_Drug_Dictionary_ID | 42674
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| Legacy Concept Name | Mitomycin_C
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 42674
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| Accepted_Therapeutic_Use_For |
Gastric Carcinoma
Pancreatic Adenocarcinoma
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
Antibiotic
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| UMLS_CUI | C0002475
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| Delete | Subject | Author | Type | Created |
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