Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Baculoviral IAP Repeat-Containing Protein 5
Synonyms
Definitions

Baculoviral IAP repeat-containing protein 5 (142 aa, ~16 kDa) is encoded by the human BIRC5 gene. This protein plays a role in the regulation of both apoptosis and the cell cycle.
ID

http://purl.obolibrary.org/obo/NCIT_C18179
code

C18179
Contributing_Source

CTRP
definition

Baculoviral IAP repeat-containing protein 5 (142 aa, ~16 kDa) is encoded by the human BIRC5 gene. This protein plays a role in the regulation of both apoptosis and the cell cycle.
DesignNote

Survivin is an apoptosis inhibitor that is expressed during the G2/M phase of the cell cycle. It is abundantly expressed in various human cancers but undetectable in normal differentiated tissues. Survivin associates with the microtubules of the mitotic spindle and any disruption results in the loss of apoptosis activity. It is physically associated with cyclin-dependent kinase p34(cdc2) on the mitotic apparatus, and is phosphorylated on Thr(34) by p34(cdc2)-cyclin B1 in vitro and in vivo. Therefore, survivin phosphorylation on Thr(34) may be required to preserve cell viability at cell division. Manipulation of this pathway may facilitate the elimination of cancer cells at mitosis. (from LocusLink)
Display_Name

Baculoviral IAP Repeat-Containing Protein 5
in_subset

http://purl.obolibrary.org/obo/NCIT_C116977

http://purl.obolibrary.org/obo/NCIT_C142800

http://purl.obolibrary.org/obo/NCIT_C142799
label

Baculoviral IAP Repeat-Containing Protein 5
Legacy Concept Name

Survivin
OMIM_Number

603352
Preferred_Name

Baculoviral IAP Repeat-Containing Protein 5
prefixIRI

NCIT:C18179
prefLabel

Baculoviral IAP Repeat-Containing Protein 5
Semantic_Type

Amino Acid, Peptide, or Protein
Swiss_Prot

O15392
UMLS_CUI

C1571495
subClassOf

http://purl.obolibrary.org/obo/NCIT_C19928
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