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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C18178
http://purl.obolibrary.org/obo/NCIT_C18178
|
|---|---|
| Preferred Name | Tumor Necrosis Factor Receptor Superfamily Member 10B |
| Definitions |
Tumor necrosis factor receptor superfamily member 10B (440 aa, ~48 kDa) is encoded by the human TNFRSF10B gene. This protein is involved in the modulation of the caspase cascade.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Tumor necrosis factor receptor superfamily member 10B (440 aa, ~48 kDa) is encoded by the human TNFRSF10B gene. This protein is involved in the modulation of the caspase cascade. |
|---|---|
| prefLabel | Tumor Necrosis Factor Receptor Superfamily Member 10B
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| label | Tumor Necrosis Factor Receptor Superfamily Member 10B
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| code | C18178
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| prefixIRI | NCIT:C18178
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| OMIM_Number | 603612
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| in_subset | |
| Display_Name | Tumor Necrosis Factor Receptor Superfamily Member 10B
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| Preferred_Name | Tumor Necrosis Factor Receptor Superfamily Member 10B
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| Contributing_Source | CTRP
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| Swiss_Prot | O14763
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| Legacy Concept Name | TRAIL_Receptor-2
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| DesignNote | Receptor for Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL). In contrast to TRAILR1, TRAILR2 mediates apoptosis via the intracellular adaptor molecule FADD. Formation of a complex between TRAIL and receptors DR4 and DR5 triggers apoptosis by inducing the oligomerization of intracellular death domains.
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| type | |
| ALT_DEFINITION | A protein on the surface of certain cells that binds another protein called TRAIL, which may kill some cancer cells. An increase in the amount or activity of death receptor 5 on cancer cells may kill more cells.
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| subClassOf | |
| Semantic_Type |
Amino Acid, Peptide, or Protein
Receptor
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| UMLS_CUI | C0664123
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