Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C18174
http://purl.obolibrary.org/obo/NCIT_C18174
Preferred Name

Tumor Necrosis Factor Receptor Superfamily Member 10A
Definitions
Tumor necrosis factor receptor superfamily member 10A (468 aa, ~50 kDa) is encoded by the human TNFRSF10A gene. This protein plays a role in the activation of caspase-dependent apoptosis.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

Tumor necrosis factor receptor superfamily member 10A (468 aa, ~50 kDa) is encoded by the human TNFRSF10A gene. This protein plays a role in the activation of caspase-dependent apoptosis.
prefLabel
Tumor Necrosis Factor Receptor Superfamily Member 10A
label
Tumor Necrosis Factor Receptor Superfamily Member 10A
code
C18174
prefixIRI
NCIT:C18174
OMIM_Number
603611
in_subset
Display_Name
Tumor Necrosis Factor Receptor Superfamily Member 10A
Preferred_Name
Tumor Necrosis Factor Receptor Superfamily Member 10A
Contributing_Source
CTRP
Swiss_Prot
O00220
Legacy Concept Name
TRAIL_Receptor-1
DesignNote
A member of the TNF family. TRAIL Receptor 1 (DR4) contains two cysteine-rich pseudorepeats resembling regions in TNFR1, DR3, and FAS, a transmembrane domain, and an intracellular death domain. Unlike FAS, TNFR1, and DR3, DR4 does not use FADD to transmit the death signal, suggesting the use of a distinct signaling machinery.
type
ALT_DEFINITION
A protein on the surface of certain cells that binds another protein called TRAIL, which may kill some cancer cells. An increase in the amount or activity of death receptor 4 on cancer cells may kill more cells.
subClassOf
Semantic_Type
Amino Acid, Peptide, or Protein
Receptor
UMLS_CUI
C1504635
Add comment
Add proposal
Delete Subject Author Type Created
No notes to display