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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Homologous Recombination | |
| Synonyms |
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| Definitions |
The process of exchange of genetic material between autonomous replicons, which depends on regions of extensive sequence homology between the participating DNA strands. This process involves double-strand breakage of one participant, resection of the break, and strand invasion, followed by formation, displacement and resolution of the Holliday junction. This process is involved in repairing broken DNA and creating combinations of genes that may be unique from the parent duplexes. Disruptions in this process can result in inviability, premature aging and predisposition to cancers and degenerative diseases. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C18144 |
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| code |
C18144
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| definition |
The process of exchange of genetic material between autonomous replicons, which depends on regions of extensive sequence homology between the participating DNA strands. This process involves double-strand breakage of one participant, resection of the break, and strand invasion, followed by formation, displacement and resolution of the Holliday junction. This process is involved in repairing broken DNA and creating combinations of genes that may be unique from the parent duplexes. Disruptions in this process can result in inviability, premature aging and predisposition to cancers and degenerative diseases.
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| label |
Homologous Recombination
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| Legacy Concept Name |
Homologous_Recombination
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| Preferred_Name |
Homologous Recombination
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| prefixIRI |
NCIT:C18144
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| prefLabel |
Homologous Recombination
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| Semantic_Type |
Genetic Function
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| UMLS_CUI |
C0599773
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| subClassOf |
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