Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C18115
http://purl.obolibrary.org/obo/NCIT_C18115
Preferred Name

Apoptosis Regulator Bcl-2
Definitions
Apoptosis regulator Bcl-2 (239 aa, ~26 kDa) is encoded by the human BCL2 gene. This protein plays a role in cellular survival.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

Apoptosis regulator Bcl-2 (239 aa, ~26 kDa) is encoded by the human BCL2 gene. This protein plays a role in cellular survival.
prefLabel
Apoptosis Regulator Bcl-2
label
Apoptosis Regulator Bcl-2
code
C18115
prefixIRI
NCIT:C18115
OMIM_Number
151430
in_subset
Display_Name
Apoptosis Regulator Bcl-2
Preferred_Name
Apoptosis Regulator Bcl-2
Contributing_Source
CTRP
Swiss_Prot
P10415
Legacy Concept Name
B-Cell_CLL_Lymphoma-2
DesignNote
A mitochondrial membrane protein, BCL-2 protein is responsible for blocking apoptosis in normal cells. Growth factor-stimulated phosphorylation by PKC promotes anti-apoptotic activity of BCL-2 during G2/M. BCL-2 regulates cell death by controlling mitochondrial membrane permeability. Cleavage by caspases during apoptosis yields a pro-apoptotic BCL-2 product that causes release of cytochrome C into the cytosol, promoting further caspase activity. Over expression from translocation t(14;18) of BCL-2 with the immunoglobulin gene region is involved in B-cell lymphomas. (from OMIM 151430 and NCI)
type
ALT_DEFINITION
A protein that helps control whether a cell lives or dies by blocking a type of cell death called apoptosis. The gene for BCL2 is found on chromosome 18, and transfer of the BCL2 gene to a different chromosome is seen in many B-cell leukemias and lymphomas. This causes the BCL2 protein to be made in larger amounts, which may keep cancer cells from dying.
subClassOf
Semantic_Type
Amino Acid, Peptide, or Protein
UMLS_CUI
C4042483
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