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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1808
http://purl.obolibrary.org/obo/NCIT_C1808
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|---|---|
| Preferred Name | Yttrium Y 90-DOTA-Biotin |
| Definitions |
A radioconjugate of biotin and yttrium Y 90 (Y-90) linked through the bifunctional macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA) with radioimmunotherapy property. Biotin is a water-soluble B-complex vitamin, present in minute amounts in every living cell, while its level in cancerous tissue is higher than that of normal tissue. Y 90-DOTA-Biotin could be used in 3-step pre-targeting radioimmunotherapy that employs a tumor targeting antibody conjugated with streptavidin, the natural ligand of biotin.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A radioconjugate of biotin and yttrium Y 90 (Y-90) linked through the bifunctional macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA) with radioimmunotherapy property. Biotin is a water-soluble B-complex vitamin, present in minute amounts in every living cell, while its level in cancerous tissue is higher than that of normal tissue. Y 90-DOTA-Biotin could be used in 3-step pre-targeting radioimmunotherapy that employs a tumor targeting antibody conjugated with streptavidin, the natural ligand of biotin. |
|---|---|
| prefLabel | Yttrium Y 90-DOTA-Biotin
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| label | Yttrium Y 90-DOTA-Biotin
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| PDQ_Closed_Trial_Search_ID | 365680
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| code | C1808
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| prefixIRI | NCIT:C1808
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| in_subset | |
| Preferred_Name | Yttrium Y 90-DOTA-Biotin
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| Maps_To | Yttrium Y 90-DOTA-Biotin
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| NCI_Drug_Dictionary_ID | 365680
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| Legacy Concept Name | _90Y-DOTA-Biotin
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| type | |
| ALT_DEFINITION | A compound that contains the radioisotope yttrium Y 90 linked to the chemical biotin. Biotin is a molecule that binds strongly to the chemical streptavidin. Yttrium Y 90 DOTA-biotin will find tumor cells in the body that have been targeted by an antibody linked to streptavidin and kill them. It is being studied together with CC49-streptavidin in the treatment of cancer.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 365680
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C0677849
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