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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1804
http://purl.obolibrary.org/obo/NCIT_C1804
|
|---|---|
| Preferred Name | Raltitrexed |
| Definitions |
A quinazoline folate analogue with antineoplastic activity. After transport into cells via the reduced folate carrier, raltitrexed undergoes intracellular polyglutamation and blocks the folate-binding site of thymidylate synthase, thereby inhibiting tetrahydrofolate activity and DNA replication and repair and resulting in cytotoxicity. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A quinazoline folate analogue with antineoplastic activity. After transport into cells via the reduced folate carrier, raltitrexed undergoes intracellular polyglutamation and blocks the folate-binding site of thymidylate synthase, thereby inhibiting tetrahydrofolate activity and DNA replication and repair and resulting in cytotoxicity. (NCI04) |
|---|---|
| prefLabel | Raltitrexed
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| label | Raltitrexed
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| PDQ_Closed_Trial_Search_ID | 42625
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| code | C1804
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| Has_Target | |
| prefixIRI | NCIT:C1804
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| in_subset |
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| Display_Name | Raltitrexed
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| Preferred_Name | Raltitrexed
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| FDA_UNII_Code | FCB9EGG971
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C21H22N4O6S
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| Maps_To | Raltitrexed
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| CAS_Registry | 112887-68-0
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| NSC Number | 639186
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| NCI_Drug_Dictionary_ID | 42625
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| Legacy Concept Name | Raltitrexed
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| type | |
| ALT_DEFINITION | An anticancer drug that stops tumor cells from growing by blocking the ability of cells to make DNA. It belongs to the family of drugs called thymidylate synthase inhibitors.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 42625
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| UMLS_CUI | C0677667
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