Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1800
http://purl.obolibrary.org/obo/NCIT_C1800
|
|---|---|
| Preferred Name | Etaracizumab |
| Definitions |
A humanized monoclonal IgG1 antibody directed against the vitronectin receptor alpha v beta 3 integrin. Etaracizumab blocks the binding of ligands, such as vitronectin, to alpha v beta 3 integrin, resulting in inhibition of angiogenesis and metastasis. Alpha v beta 3 integrin is a cell adhesion and signaling receptor that is expressed on the surface of tumor vessel endothelial cells, some tumor cells, and a number of other cell types.
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A humanized monoclonal IgG1 antibody directed against the vitronectin receptor alpha v beta 3 integrin. Etaracizumab blocks the binding of ligands, such as vitronectin, to alpha v beta 3 integrin, resulting in inhibition of angiogenesis and metastasis. Alpha v beta 3 integrin is a cell adhesion and signaling receptor that is expressed on the surface of tumor vessel endothelial cells, some tumor cells, and a number of other cell types. |
|---|---|
| prefLabel | Etaracizumab
|
| label | Etaracizumab
|
| PDQ_Closed_Trial_Search_ID | 38491
|
| code | C1800
|
| Has_Target | |
| prefixIRI | NCIT:C1800
|
| in_subset |
See more
See less
|
| Display_Name | Etaracizumab
|
| Preferred_Name | Etaracizumab
|
| FDA_UNII_Code | 41W9MFI160
|
| Contributing_Source |
CTRP
FDA
|
| Maps_To | Etaracizumab
|
| CAS_Registry | 892553-42-3
|
| NSC Number | 719850
|
| NCI_Drug_Dictionary_ID | 38491
|
| Legacy Concept Name | Vitaxin
|
| type | |
| ALT_DEFINITION | A substance being studied in the treatment of some types of cancer and other conditions. Abegrin binds to a protein on the surface of blood vessels and may prevent the growth of new blood vessels that tumors need to grow. It may also prevent the spread of cancer. It is a type of antiangiogenesis agent, a type of metastasis inhibitor, and a type of monoclonal antibody.
|
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 38491
|
| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
Immunologic Factor
|
| UMLS_CUI | C2350723
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |