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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C17984
http://purl.obolibrary.org/obo/NCIT_C17984
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|---|---|
| Preferred Name | Prostaglandin G/H Synthase 2 |
| Definitions |
Prostaglandin G/H synthase 2 (604 aa, ~69 kDa) is encoded by the human PTGS2 gene. This protein plays a role in prostaglandin metabolism.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Prostaglandin G/H synthase 2 (604 aa, ~69 kDa) is encoded by the human PTGS2 gene. This protein plays a role in prostaglandin metabolism. |
|---|---|
| prefLabel | Prostaglandin G/H Synthase 2
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| label | Prostaglandin G/H Synthase 2
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| code | C17984
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| prefixIRI | NCIT:C17984
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| OMIM_Number | 600262
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| in_subset | |
| Display_Name | Prostaglandin G/H Synthase 2
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| Preferred_Name | Prostaglandin G/H Synthase 2
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| Contributing_Source | CTRP
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| Swiss_Prot | P35354
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| Legacy Concept Name | Prostaglandin-Endoperoxide_Synthase-2
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| DesignNote | A rate-limiting enzyme in the conversion of arachidonic acid to prostaglandins, COX-2 is expressed in cells involved in inflammatory processes and has been implicated in tumor promotion as well as a negative prognosis. COX-2 is expressed in 50% of pancreatic tumors. Anti-inflammatory glucocorticoids are potent inhibitors of cyclooxygenase. Inhibition or lack of COX-2 reduces tumor growth and blocks angiogenesis. Aspirin and etodolac, both COX-2 inhibitors, inhibit growth of pancreatic cancer cell lines. (from Cancer 2001. 91:333, Medscape, and OMIM 600262)
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| type | |
| ALT_DEFINITION | An enzyme that speeds up the formation of substances that cause inflammation and pain. It may also cause tumor cells to grow. Some tumors have high levels of COX-2 and blocking its activity may reduce tumor growth.
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| subClassOf | |
| Semantic_Type |
Amino Acid, Peptide, or Protein
Enzyme
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| UMLS_CUI | C1565860
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