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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1798
http://purl.obolibrary.org/obo/NCIT_C1798
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|---|---|
| Preferred Name | Shark Cartilage Extract AE-941 |
| Definitions |
A multifunctional antiangiogenic agent derived from shark cartilage with potential antineoplastic activity. Shark cartilage extract AE-941 competitively inhibits the binding of pro-angiogenic vascular endothelial growth factor (VEGF) to its cellular receptor, thereby inhibiting endothelial cell proliferation. This agent also inhibits matrix metalloproteinases (MMPs), stimulates tissue plasminogen activator (tPA), and activates caspase-mediated apoptotic pathways in endothelial cells.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A multifunctional antiangiogenic agent derived from shark cartilage with potential antineoplastic activity. Shark cartilage extract AE-941 competitively inhibits the binding of pro-angiogenic vascular endothelial growth factor (VEGF) to its cellular receptor, thereby inhibiting endothelial cell proliferation. This agent also inhibits matrix metalloproteinases (MMPs), stimulates tissue plasminogen activator (tPA), and activates caspase-mediated apoptotic pathways in endothelial cells. |
|---|---|
| prefLabel | Shark Cartilage Extract AE-941
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| label | Shark Cartilage Extract AE-941
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| PDQ_Closed_Trial_Search_ID | 42021
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| code | C1798
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| Has_Target | |
| prefixIRI | NCIT:C1798
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| in_subset |
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| Display_Name | Shark Cartilage Extract AE-941
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| Preferred_Name | Shark Cartilage Extract AE-941
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| Contributing_Source | CTRP
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| Maps_To | Shark Cartilage Extract AE-941
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| CAS_Registry | 305838-77-1
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| NSC Number | 706456
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| NCI_Drug_Dictionary_ID | 42021
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| Legacy Concept Name | Neovastat
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| type | |
| ALT_DEFINITION | A substance made from shark cartilage that is being studied for its ability to prevent the growth of new blood vessels that tumors need to grow. It is a type of antiangiogenesis agent.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 42021
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C1963096
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