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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1795
http://purl.obolibrary.org/obo/NCIT_C1795
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|---|---|
| Preferred Name | Paclitaxel Poliglumex |
| Definitions |
The agent paclitaxel linked to a biodegradable, water-soluble polyglutamate polymer with antineoplastic properties. The polyglutamate residue increases the water solubility of paclitaxel and allows delivery of higher doses than those achievable with paclitaxel alone. Paclitaxel promotes microtubule assembly and prevents microtubule depolymerization, thus interfering with normal mitosis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The agent paclitaxel linked to a biodegradable, water-soluble polyglutamate polymer with antineoplastic properties. The polyglutamate residue increases the water solubility of paclitaxel and allows delivery of higher doses than those achievable with paclitaxel alone. Paclitaxel promotes microtubule assembly and prevents microtubule depolymerization, thus interfering with normal mitosis. |
|---|---|
| prefLabel | Paclitaxel Poliglumex
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| label | Paclitaxel Poliglumex
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| PDQ_Closed_Trial_Search_ID | 38325
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| code | C1795
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| prefixIRI | NCIT:C1795
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| in_subset |
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| Display_Name | Paclitaxel Poliglumex
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| Preferred_Name | Paclitaxel Poliglumex
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| FDA_UNII_Code | TQ64FZ98ZN
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C10H16N2O7(C52H56N2O16)n(C5H7NO3)n
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| Maps_To | Paclitaxel Poliglumex
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| CAS_Registry | 263351-82-2
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| NSC Number | 724773
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| NCI_Drug_Dictionary_ID | 38325
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| Legacy Concept Name | Paclitaxel_Polyglutamate
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| type | |
| ALT_DEFINITION | A form of the anticancer drug paclitaxel combined with a protein called poliglumex that may have fewer side effects and work better than paclitaxel. It is being studied in the treatment of breast cancer, ovarian cancer, lung cancer, and other types of cancer. It belongs to the family of drugs called mitotic inhibitors.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 38325
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C1702776
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