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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Omacetaxine | |
| Synonyms |
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| Definitions |
A protein translation inhibitor and cytotoxic plant alkaloid homoharringtonine isolated from the evergreen tree Cephalotaxus, with potential antineoplastic activity. Although the exact mechanism of action has not been fully elucidated, upon administration, omacetaxine targets and binds to the 80S ribosome in eukaryotic cells and inhibits protein synthesis by interfering with chain elongation. This reduces levels of certain oncoproteins and anti-apoptotic proteins. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C179199 |
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| CAS_Registry |
24316-19-6
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| Chemical_Formula |
C18H21NO4
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|
| code |
C179199
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| Contributing_Source |
CTRP FDA
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|
| definition |
A protein translation inhibitor and cytotoxic plant alkaloid homoharringtonine isolated from the evergreen tree Cephalotaxus, with potential antineoplastic activity. Although the exact mechanism of action has not been fully elucidated, upon administration, omacetaxine targets and binds to the 80S ribosome in eukaryotic cells and inhibits protein synthesis by interfering with chain elongation. This reduces levels of certain oncoproteins and anti-apoptotic proteins.
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| Display_Name |
Omacetaxine
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| FDA_UNII_Code |
84MI6OYN4Z
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| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
|
| label |
Omacetaxine
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| NCI_Drug_Dictionary_ID |
805708
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| NCI_META_CUI |
CL1648440
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| Preferred_Name |
Omacetaxine
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| prefixIRI |
NCIT:C179199
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| prefLabel |
Omacetaxine
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| subClassOf |
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