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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Infliximab | |
| Synonyms |
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|
| Definitions |
A recombinant chimeric, mouse-human monoclonal antibody directed against tumor necrosis factor alpha (TNF-alpha), a protein involved in inflammation, cell survival, and apoptosis. Infliximab may be pro- apoptotic or anti-apoptotic, depending on cell type. (NCI04) |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C1789 |
|
| Accepted_Therapeutic_Use_For |
Ankylosis spondylitis; Crohns disease; Plaque psoriasis; Rheumatoid arthritis; Sarcoidosis
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| ALT_DEFINITION |
A monoclonal antibody that blocks the action of a cytokine called tumor necrosis factor alfa. It is being studied in the treatment and prevention of weight loss and loss of appetite in patients with advanced cancer. It belongs to the family of drugs called monoclonal antibodies.
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| CAS_Registry |
170277-31-3
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|
| code |
C1789
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|
| Contributing_Source |
CTRP FDA
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|
| definition |
A recombinant chimeric, mouse-human monoclonal antibody directed against tumor necrosis factor alpha (TNF-alpha), a protein involved in inflammation, cell survival, and apoptosis. Infliximab may be pro- apoptotic or anti-apoptotic, depending on cell type. (NCI04)
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|
| Display_Name |
Infliximab
|
|
| FDA_UNII_Code |
B72HH48FLU
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| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Infliximab
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|
| Legacy Concept Name |
Infliximab
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|
| Maps_To |
Infliximab
|
|
| NCI_Drug_Dictionary_ID |
38698
|
|
| NSC Number |
728729
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| PDQ_Closed_Trial_Search_ID |
38698
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|
| PDQ_Open_Trial_Search_ID |
38698
|
|
| Preferred_Name |
Infliximab
|
|
| prefixIRI |
NCIT:C1789
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|
| prefLabel |
Infliximab
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|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance
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| UMLS_CUI |
C0666743
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| subClassOf |
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