Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C1789
http://purl.obolibrary.org/obo/NCIT_C1789
Preferred Name

Infliximab
Definitions
A recombinant chimeric, mouse-human monoclonal antibody directed against tumor necrosis factor alpha (TNF-alpha), a protein involved in inflammation, cell survival, and apoptosis. Infliximab may be pro- apoptotic or anti-apoptotic, depending on cell type. (NCI04)
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A recombinant chimeric, mouse-human monoclonal antibody directed against tumor necrosis factor alpha (TNF-alpha), a protein involved in inflammation, cell survival, and apoptosis. Infliximab may be pro- apoptotic or anti-apoptotic, depending on cell type. (NCI04)
prefLabel
Infliximab
label
Infliximab
PDQ_Closed_Trial_Search_ID
38698
code
C1789
Has_Target
prefixIRI
NCIT:C1789
in_subset
Display_Name
Infliximab
Preferred_Name
Infliximab
FDA_UNII_Code
B72HH48FLU
Contributing_Source
CTRP
FDA
Maps_To
Infliximab
CAS_Registry
170277-31-3
NSC Number
728729
NCI_Drug_Dictionary_ID
38698
Legacy Concept Name
Infliximab
type
ALT_DEFINITION
A monoclonal antibody that blocks the action of a cytokine called tumor necrosis factor alfa. It is being studied in the treatment and prevention of weight loss and loss of appetite in patients with advanced cancer. It belongs to the family of drugs called monoclonal antibodies.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
38698
Accepted_Therapeutic_Use_For
Ankylosis spondylitis; Crohns disease; Plaque psoriasis; Rheumatoid arthritis; Sarcoidosis
Semantic_Type
Amino Acid, Peptide, or Protein
Pharmacologic Substance
UMLS_CUI
C0666743
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