Biological and Environmental Research Ontology

Last uploaded: December 23, 2022

Id	http://purl.obolibrary.org/obo/NCIT_C1788 http://purl.obolibrary.org/obo/NCIT_C1788
Preferred Name	Aprinocarsen
Definitions	A synthetic phosphorothioate oligodeoxynucleotide. As an antisense molecule, aprinocarsen hybridizes to the 3-untranslated region of the human protein kinase C (PKC-alpha) mRNA, thereby inhibiting PKC-alpha expression and growth of PKC-alpha-dependent tumor cells. (NCI04)
Type	http://www.w3.org/2002/07/owl#Class

definition	A synthetic phosphorothioate oligodeoxynucleotide. As an antisense molecule, aprinocarsen hybridizes to the 3-untranslated region of the human protein kinase C (PKC-alpha) mRNA, thereby inhibiting PKC-alpha expression and growth of PKC-alpha-dependent tumor cells. (NCI04)
prefLabel	Aprinocarsen
label	Aprinocarsen
PDQ_Closed_Trial_Search_ID	42953
code	C1788
prefixIRI	NCIT:C1788
in_subset	http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C128784 http://purl.obolibrary.org/obo/NCIT_C157711 http://purl.obolibrary.org/obo/NCIT_C157712 See more See less
Preferred_Name	Aprinocarsen
FDA_UNII_Code	FMT95051CQ
Contributing_Source	FDA
Maps_To	Aprinocarsen PKC-alpha Antisense Oligodeoxynucleotide ISIS 3521
CAS_Registry	151879-73-1
NSC Number	719337
NCI_Drug_Dictionary_ID	42953
Legacy Concept Name	ISIS_3521
type	http://www.w3.org/2002/07/owl#Class
ALT_DEFINITION	A substance that is being studied in the treatment of cancer.
Is_Value_For_GDC_Property	http://purl.obolibrary.org/obo/NCIT_C1909
subClassOf	http://purl.obolibrary.org/obo/NCIT_C1291
PDQ_Open_Trial_Search_ID	42953
Semantic_Type	Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide
UMLS_CUI	C0666551

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