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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 | |
| Synonyms |
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| Definitions |
Dual specificity mitogen-activated protein kinase kinase 1 (393 aa, ~43 kDa) is encoded by the human MAP2K1 gene. This protein plays a role in protein phosphorylation and the MAP kinase signal transduction pathway. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C17808 |
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| code |
C17808
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| Contributing_Source |
CTRP
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| definition |
Dual specificity mitogen-activated protein kinase kinase 1 (393 aa, ~43 kDa) is encoded by the human MAP2K1 gene. This protein plays a role in protein phosphorylation and the MAP kinase signal transduction pathway.
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| DesignNote |
A component of the RAS intracellular signaling pathway, MAP2K1 is a critical activating protein kinase of MAP kinase. p53 activates NFKB through a RAF/MAP2K1/p90(RSK) pathway. (Yu et al. Curr Biol 1998. 8:56-64 and OMIMI)
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| Display_Name |
Dual Specificity Mitogen-Activated Protein Kinase Kinase 1
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C116977 |
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| label |
Dual Specificity Mitogen-Activated Protein Kinase Kinase 1
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| Legacy Concept Name |
MAP2K1_Protein
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| OMIM_Number |
176872
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| Preferred_Name |
Dual Specificity Mitogen-Activated Protein Kinase Kinase 1
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| prefixIRI |
NCIT:C17808
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| prefLabel |
Dual Specificity Mitogen-Activated Protein Kinase Kinase 1
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| Semantic_Type |
Amino Acid, Peptide, or Protein Enzyme
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| Swiss_Prot |
Q02750
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| UMLS_CUI |
C1434639
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| subClassOf |
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