Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Mitogen-Activated Protein Kinase 8
Synonyms
Definitions

Mitogen-activated protein kinase 8 (427 aa, ~48 kDa) is encoded by the human MAPK8 gene. This protein plays a role in serine/threonine phosphorylation, apoptosis and toll-like receptor signaling.
ID

http://purl.obolibrary.org/obo/NCIT_C17780
code

C17780
definition

Mitogen-activated protein kinase 8 (427 aa, ~48 kDa) is encoded by the human MAPK8 gene. This protein plays a role in serine/threonine phosphorylation, apoptosis and toll-like receptor signaling.
DesignNote

Inhibited by dual specificity phosphatases, and phosphothreonine/tyrosine activated by a Ras-dependent dual specificity MAP2K4/MAP2K7 cascade, MAPK8 mediates immediate-early gene expression. MAPK8 binds scaffolding proteins MAPK8IP1/2/3. MAPK8/UV-induced apoptosis appears related to cytochrome c-mediated cell death. MAPK8 activation by TNF-alpha induces apoptosis. MAPK8 appears to be required for T-helper cell differentiation into Th1 cells.
label

Mitogen-Activated Protein Kinase 8
Legacy Concept Name

MAP-Kinase-8
OMIM_Number

601158
Preferred_Name

Mitogen-Activated Protein Kinase 8
prefixIRI

NCIT:C17780
prefLabel

Mitogen-Activated Protein Kinase 8
Semantic_Type

Amino Acid, Peptide, or Protein

Enzyme
Swiss_Prot

P45983
UMLS_CUI

C0380051
subClassOf

http://purl.obolibrary.org/obo/NCIT_C16376
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