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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C17778
http://purl.obolibrary.org/obo/NCIT_C17778
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|---|---|
| Preferred Name | 26S Proteasome Non-ATPase Regulatory Subunit 10 |
| Definitions |
26S proteasome non-ATPase regulatory subunit 10 (226 aa, ~24 kDa) is encoded by the human PSMD10 gene. This protein is involved in both the assembly of the 26S proteasome, ubiquitin-dependent protein degradation and signaling pathway regulation.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | 26S proteasome non-ATPase regulatory subunit 10 (226 aa, ~24 kDa) is encoded by the human PSMD10 gene. This protein is involved in both the assembly of the 26S proteasome, ubiquitin-dependent protein degradation and signaling pathway regulation. |
|---|---|
| label | 26S Proteasome Non-ATPase Regulatory Subunit 10
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| prefLabel | 26S Proteasome Non-ATPase Regulatory Subunit 10
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| Legacy Concept Name | Proteasome-26S_Subunit_Non-ATPase-10
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| in_subset | |
| Preferred_Name | 26S Proteasome Non-ATPase Regulatory Subunit 10
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| Display_Name | 26S Proteasome Non-ATPase Regulatory Subunit 10
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| Swiss_Prot | O75832
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| DesignNote | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. This protein is a non-ATPase subunit of the 19S regulator. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. (from LocusLink)
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| UMLS_CUI | C0911800
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| prefixIRI | NCIT:C17778
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| Contributing_Source | CTRP
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| subClassOf | |
| code | C17778
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| type | |
| OMIM_Number | 300880
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| Semantic_Type | Amino Acid, Peptide, or Protein
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