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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C17772
http://purl.obolibrary.org/obo/NCIT_C17772
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|---|---|
| Preferred Name | CD44 Antigen |
| Definitions |
CD44 antigen (742 aa, ~82 kDa) is encoded by the human CD44 gene. This protein is involved in cell-cell adhesion and cell-matrix adhesion.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | CD44 antigen (742 aa, ~82 kDa) is encoded by the human CD44 gene. This protein is involved in cell-cell adhesion and cell-matrix adhesion. |
|---|---|
| prefLabel | CD44 Antigen
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| label | CD44 Antigen
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| code | C17772
|
| prefixIRI | NCIT:C17772
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| OMIM_Number | 107269
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| in_subset | |
| Display_Name | CD44 Antigen
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| Preferred_Name | CD44 Antigen
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| Contributing_Source | CTRP
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| Swiss_Prot | P16070
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| Legacy Concept Name | CD44_Antigen
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| DesignNote | Acidic sulfated integral membrane glycoproteins expressed in several alternatively spliced and variable glycosylated forms on a wide variety of cell types including mature T-cells, B-cells, medullary thymocytes, granulocytes, macrophages, erythrocytes, and fibroblasts. CD44 antigens are the principle cell surface receptors for hyaluronate and this interaction mediates binding of lymphocytes to high endothelial venules. (From Abbas et al., Cellular and Molecular Immunology, 2d ed, p156)
CD44 antigen exists as multiple isoforms generated by alternative splicing. Some splice variants have other biological functions and some are seen more frequently in tumors.
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| type | |
| subClassOf | |
| Semantic_Type |
Amino Acid, Peptide, or Protein
Immunologic Factor
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| UMLS_CUI | C1097299
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