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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C17685
http://purl.obolibrary.org/obo/NCIT_C17685
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|---|---|
| Preferred Name | Receptor Tyrosine-Protein Kinase ErbB-4 |
| Definitions |
Receptor tyrosine-protein kinase erbB-4 (1308 aa, ~147 kDa) is encoded by the human ERBB4 gene. This protein is involved in multicellular organismal development, cell proliferation and signal transduction.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Receptor tyrosine-protein kinase erbB-4 (1308 aa, ~147 kDa) is encoded by the human ERBB4 gene. This protein is involved in multicellular organismal development, cell proliferation and signal transduction. |
|---|---|
| label | Receptor Tyrosine-Protein Kinase ErbB-4
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| prefLabel | Receptor Tyrosine-Protein Kinase ErbB-4
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| Legacy Concept Name | ERBB4_Receptor_Protein_Tyrosine_Kinase
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| in_subset | |
| Preferred_Name | Receptor Tyrosine-Protein Kinase ErbB-4
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| Display_Name | Receptor Tyrosine-Protein Kinase ErbB-4
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| Swiss_Prot | Q15303
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| DesignNote | ErbB4 heterodimerizes with other type I receptor tyrosine kinases. In the peripheral nervous system, ErbB4 helps regulate glial proliferation and acts as a signaling molecule at the neuromuscular junction. In the mature CNS, ErbB4 is expressed in cerebellar granule cells and in a subset of cells that also express the neurotransmitter: aminobutyric acid. ErbB4 is critical in cardiac development. It is overexpressed frequently in several common solid tumors, including in breast cancer.
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| UMLS_CUI | C0214098
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| prefixIRI | NCIT:C17685
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| Contributing_Source | CTRP
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| subClassOf | |
| code | C17685
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| type | |
| OMIM_Number | 600543
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Receptor
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