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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C17680
http://purl.obolibrary.org/obo/NCIT_C17680
|
|---|---|
| Preferred Name | Cyclin-Dependent Kinase 4 |
| Definitions |
Cyclin-dependent kinase 4 (303 aa, ~34 kDa) is encoded by the human CDK4 gene. This protein may be involved in cell cycle regulation.
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Cyclin-dependent kinase 4 (303 aa, ~34 kDa) is encoded by the human CDK4 gene. This protein may be involved in cell cycle regulation. |
|---|---|
| prefLabel | Cyclin-Dependent Kinase 4
|
| label | Cyclin-Dependent Kinase 4
|
| code | C17680
|
| prefixIRI | NCIT:C17680
|
| OMIM_Number | 123829
|
| in_subset | |
| Display_Name | Cyclin-Dependent Kinase 4
|
| Preferred_Name | Cyclin-Dependent Kinase 4
|
| Contributing_Source | CTRP
|
| Swiss_Prot | P11802
|
| Legacy Concept Name | Cyclin-Dependent_Kinase-4
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| DesignNote | A serine/threonine protein kinase involved in cell cycle control, Cdk4 may complex with D-type G1 Cyclins and belongs to the CDC2/CDKX subfamily. CDK4/CDK6 phosphorylates Rb in early G1, displacing histone deacetylase and blocking transcriptional repression. CDK4 is inhibited by p16 (Cyclin-Dependent Kinase Inhibitor-2).
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| type | |
| subClassOf | |
| Semantic_Type |
Amino Acid, Peptide, or Protein
Enzyme
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| UMLS_CUI | C1527860
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