An extract derived from the Muscadine grape (Vitis rotundifolia), with potential anti-inflammatory, antioxidant, anti-lipidemic and chemopreventive activities. The muscadine grape extract (MGE) contains numerous phytochemicals including hydrolyzable tannins and flavonoids, such as resveratrol, anthocyanin 3,5-diglucosides, quercetin, ellagic acid, myricetin, and kaempferol glycosides. Upon administration, the active components in the MGE scavenge free radicals, protect against oxidation of low-density lipoprotein (LDL), and inhibit cell damage due to reactive oxygen species (ROS). This inhibits oxidative stress and protects against DNA damage. MGE also inhibits enzymes involved in inflammation, cell replication and DNA synthesis, and induces the expression of anti-oxidant enzymes. The active ingredients may also inhibit certain signaling pathways upregulated in some tumor cell types, eventually leading to apoptosis and a reduction in tumor cell proliferation. MGE may also boost energy and prevent fatigue.