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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C175508
http://purl.obolibrary.org/obo/NCIT_C175508
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|---|---|
| Preferred Name | Anti-BTN3A Agonistic Monoclonal Antibody ICT01 |
| Definitions |
A humanized agonistic monoclonal antibody directed against butyrophilin subfamily 3 member A (BTN3A; CD277), with potential immunomodulating and antineoplastic activities. Upon administration, the anti-BTN3A agonistic monoclonal antibody ICT01 targets and binds to BTN3A present on epithelial and tumor cells. BTN3A binding may sensitize tumor cells to gamma 9 delta 2 (Vg9Vd2) T cell killing. The Vg9Vd2 T cells secrete effector cytokines and exert a cytolytic effect on tumor cells. This may abrogate BTN3A-mediated tumor immunity and may enhance anti-tumor immune response. BTN3A, a member of the butyrophilin superfamily of immunomodulators, is upregulated in tumor cells.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A humanized agonistic monoclonal antibody directed against butyrophilin subfamily 3 member A (BTN3A; CD277), with potential immunomodulating and antineoplastic activities. Upon administration, the anti-BTN3A agonistic monoclonal antibody ICT01 targets and binds to BTN3A present on epithelial and tumor cells. BTN3A binding may sensitize tumor cells to gamma 9 delta 2 (Vg9Vd2) T cell killing. The Vg9Vd2 T cells secrete effector cytokines and exert a cytolytic effect on tumor cells. This may abrogate BTN3A-mediated tumor immunity and may enhance anti-tumor immune response. BTN3A, a member of the butyrophilin superfamily of immunomodulators, is upregulated in tumor cells. |
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| prefLabel | Anti-BTN3A Agonistic Monoclonal Antibody ICT01
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| label | Anti-BTN3A Agonistic Monoclonal Antibody ICT01
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| NCI_META_CUI | CL1412871
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| PDQ_Closed_Trial_Search_ID | 802942
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| code | C175508
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| prefixIRI | NCIT:C175508
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| in_subset |
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| Display_Name | Anti-BTN3A Agonistic Monoclonal Antibody ICT01
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| Preferred_Name | Anti-BTN3A Agonistic Monoclonal Antibody ICT01
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| Contributing_Source | CTRP
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| Maps_To | Anti-BTN3A Agonistic Monoclonal Antibody ICT01
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| NCI_Drug_Dictionary_ID | 802942
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 802942
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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