Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
Jump to:
| Id | http://purl.obolibrary.org/obo/NCIT_C1755
http://purl.obolibrary.org/obo/NCIT_C1755
|
|---|---|
| Preferred Name | Pentosan Polysulfate |
| Definitions |
A semisynthetic heparin-like glucosaminoglycan. Although its mechanism of action is unknown, pentosan polysulfate may act as a buffer to control cell permeability by preventing irritating solutes from reaching cells coated with it. Administered orally, excreted pentosan polysulfate adheres to the urinary bladder wall, preventing irritants from entering bladder cells and the development or progression of interstitial cystitis (IC), a complication of some chemotherapies. This agent also exhibits anticoagulant and fibrinolytic properties. (NCI04)
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A semisynthetic heparin-like glucosaminoglycan. Although its mechanism of action is unknown, pentosan polysulfate may act as a buffer to control cell permeability by preventing irritating solutes from reaching cells coated with it. Administered orally, excreted pentosan polysulfate adheres to the urinary bladder wall, preventing irritants from entering bladder cells and the development or progression of interstitial cystitis (IC), a complication of some chemotherapies. This agent also exhibits anticoagulant and fibrinolytic properties. (NCI04) |
|---|---|
| label |
Pentosan Polysulfate
|
| prefLabel |
Pentosan Polysulfate
|
| Legacy Concept Name |
Pentosan_Polysulfate
|
| in_subset | |
| Preferred_Name |
Pentosan Polysulfate
|
| Chemical_Formula |
(C5H8O10S2)n
|
| UMLS_CUI |
C0030888
|
| FDA_UNII_Code |
F59P8B75R4
|
| prefixIRI |
NCIT:C1755
|
| Contributing_Source |
FDA
|
| subClassOf | |
| Has_Salt_Form | |
| code |
C1755
|
| type | |
| ALT_DEFINITION |
A drug used to relieve pain or discomfort associated with chronic inflammation of the bladder. It is also being evaluated for its protective effects on the gastrointestinal tract in people undergoing radiation therapy.
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
|
| CAS_Registry |
37300-21-3
39432-58-1
|
Add comment
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |