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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C17546
http://purl.obolibrary.org/obo/NCIT_C17546
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|---|---|
| Preferred Name | Transcription Factor E2F1 |
| Definitions |
Transcription factor E2F1 (437 aa, ~47 kDa) is encoded by the human E2F1 gene. This protein is involved in the regulation of apoptosis, gene transcription, cell cycle progression and cell proliferation.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Transcription factor E2F1 (437 aa, ~47 kDa) is encoded by the human E2F1 gene. This protein is involved in the regulation of apoptosis, gene transcription, cell cycle progression and cell proliferation. |
|---|---|
| prefLabel | Transcription Factor E2F1
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| label | Transcription Factor E2F1
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| code | C17546
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| prefixIRI | NCIT:C17546
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| OMIM_Number | 189971
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| in_subset | |
| Display_Name | Transcription Factor E2F1
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| Preferred_Name | Transcription Factor E2F1
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| Contributing_Source | CTRP
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| Swiss_Prot | Q01094
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| Legacy Concept Name | E2F_Transcription_Factor-1
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| DesignNote | Transcription factor E2F1 binds DNA cooperatively with Dp proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. It activates p53 and p73 gene expression. MYC-induced apoptosis involves E2F1. E2F1 can induce apoptosis in a p53-independent manner by accumulation of p73 or by a death receptor-dependent mechanism via down regulating TRAF2 and inhibiting activation of NFKB anti-apoptotic signals. E2F1 induces p53-dependent apoptosis by inducing ARF, which neutralizes MDM2 and stabilizes p53. E2F is a critical determinant of G1/S transition, activating transcription of genes necessary for DNA replication. RB interacts with E2F factors to arrest cells in G1 by active transcriptional repression. RB/E2F repression mediates G1 arrest triggered by TGFB, by p16(INK4A), and by contact inhibition. Accumulation of G1 cyclins E and D1 is regulated by E2F1. TCR-AICD, in a p53-independent late G1 phase cell-cycle checkpoint, is dependent on E2F1 and TP73. (OMIM and UniProt)
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| type | |
| subClassOf | |
| Semantic_Type | Amino Acid, Peptide, or Protein
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| UMLS_CUI | C1506928
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