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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C175411
http://purl.obolibrary.org/obo/NCIT_C175411
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|---|---|
| Preferred Name | Anti-Lewis B/Lewis Y Monoclonal Antibody GNX102 |
| Definitions |
A humanized monoclonal antibody directed against human tumor-associated carbohydrate antigens (TACAs) Lewis B (LeB) and Lewis Y (LeY), with potential antineoplastic activity. Upon administration, anti-LeB/LeY monoclonal antibody GNX102 binds to branched LeB and LeY glycans, which may induce an antibody-dependent cellular cytotoxicity (ADCC) response against LeB- and LeY-expressing tumor cells. LeB and LeY antigens, tetrasaccharides with low to moderate expression in monomeric form in normal adult tissues, is overexpressed in branched form in multiple forms of cancers.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A humanized monoclonal antibody directed against human tumor-associated carbohydrate antigens (TACAs) Lewis B (LeB) and Lewis Y (LeY), with potential antineoplastic activity. Upon administration, anti-LeB/LeY monoclonal antibody GNX102 binds to branched LeB and LeY glycans, which may induce an antibody-dependent cellular cytotoxicity (ADCC) response against LeB- and LeY-expressing tumor cells. LeB and LeY antigens, tetrasaccharides with low to moderate expression in monomeric form in normal adult tissues, is overexpressed in branched form in multiple forms of cancers. |
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| prefLabel | Anti-Lewis B/Lewis Y Monoclonal Antibody GNX102
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| label | Anti-Lewis B/Lewis Y Monoclonal Antibody GNX102
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| NCI_META_CUI | CL1412719
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| PDQ_Closed_Trial_Search_ID | 803029
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| code | C175411
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| Has_Target | |
| prefixIRI | NCIT:C175411
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| in_subset |
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| Display_Name | Anti-Lewis B/Lewis Y Monoclonal Antibody GNX102
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| Preferred_Name | Anti-Lewis B/Lewis Y Monoclonal Antibody GNX102
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| Contributing_Source | CTRP
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| Maps_To | Anti-Lewis B/Lewis Y Monoclonal Antibody GNX102
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| NCI_Drug_Dictionary_ID | 803029
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 803029
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| Semantic_Type | Pharmacologic Substance
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