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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C17532
http://purl.obolibrary.org/obo/NCIT_C17532
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|---|---|
| Preferred Name | Retinoic Acid Receptor |
| Definitions |
Retinoid receptors (RARA, RARB, RARG) require co-regulators to increase selective binding to DNA response elements in target genes and enhance transcriptional activity.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Retinoid receptors (RARA, RARB, RARG) require co-regulators to increase selective binding to DNA response elements in target genes and enhance transcriptional activity. |
|---|---|
| prefLabel | Retinoic Acid Receptor
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| label | Retinoic Acid Receptor
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| code | C17532
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| prefixIRI | NCIT:C17532
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| in_subset | |
| Display_Name | Retinoic Acid Receptor
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| Preferred_Name | Retinoic Acid Receptor
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| Contributing_Source | CTRP
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| Legacy Concept Name | Retinoic_Acid_Receptor
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| DesignNote | A protein that binds retinoic acid with high affinity. Binding of ligand to RARs attracts co-activator proteins containing a NR box. NCOR1 and SMRT contain CoRNR box sequences, similar to the NR box, in receptor interaction domains and mediate inhibition of gene transcription by RARs. Sequences flanking the CoRNR box determine receptor specificity. Differential recognition of receptors by co-activators and co-repressors is due to subtle differences between CoRNR and NR boxes. The association of SMRT with receptors is destabilized by ligand, triggering the activation process. (from OMIM 180240 and NCI)
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| type | |
| subClassOf | |
| Semantic_Type |
Amino Acid, Peptide, or Protein
Receptor
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| UMLS_CUI | C0140278
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