Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C175301
http://purl.obolibrary.org/obo/NCIT_C175301
|
|---|---|
| Preferred Name | Thorium Th 227 Anti-PSMA Monoclonal Antibody BAY 2315497 |
| Definitions |
A radioimmunoconjugate consisting of a monoclonal antibody targeting the tumor-associated antigen (TAA) human prostate-specific membrane antigen (PSMA) and labeled, via a 3-hydroxypyridin-2-one (3,2-HOPO) chelator, with the alpha-emitting radioisotope thorium Th 227, with potential antineoplastic activity. Upon administration, the monoclonal antibody moiety of BAY 2315497 targets and specifically binds to PSMA on tumor cells, delivering a cytotoxic dose of alpha radiation to cells expressing PSMA. PSMA is overexpressed on the surface of metastatic and hormone-refractory prostate cancer cells.
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A radioimmunoconjugate consisting of a monoclonal antibody targeting the tumor-associated antigen (TAA) human prostate-specific membrane antigen (PSMA) and labeled, via a 3-hydroxypyridin-2-one (3,2-HOPO) chelator, with the alpha-emitting radioisotope thorium Th 227, with potential antineoplastic activity. Upon administration, the monoclonal antibody moiety of BAY 2315497 targets and specifically binds to PSMA on tumor cells, delivering a cytotoxic dose of alpha radiation to cells expressing PSMA. PSMA is overexpressed on the surface of metastatic and hormone-refractory prostate cancer cells. |
|---|---|
| prefLabel | Thorium Th 227 Anti-PSMA Monoclonal Antibody BAY 2315497
|
| label | Thorium Th 227 Anti-PSMA Monoclonal Antibody BAY 2315497
|
| NCI_META_CUI | CL1412652
|
| PDQ_Closed_Trial_Search_ID | 803273
|
| code | C175301
|
| Has_Target | |
| prefixIRI | NCIT:C175301
|
| in_subset |
See more
See less
|
| Display_Name | Thorium Th 227 Anti-PSMA Monoclonal Antibody BAY 2315497
|
| Preferred_Name | Thorium Th 227 Anti-PSMA Monoclonal Antibody BAY 2315497
|
| Contributing_Source | CTRP
|
| Maps_To | Thorium Th 227 Anti-PSMA Monoclonal Antibody BAY 2315497
|
| NCI_Drug_Dictionary_ID | 803273
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 803273
|
| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |