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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C17489
http://purl.obolibrary.org/obo/NCIT_C17489
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|---|---|
| Preferred Name | Cytotoxic T-Lymphocyte Protein 4 |
| Definitions |
Cytotoxic T-lymphocyte protein 4 (223 aa, ~25 kDa) is encoded by the human CTLA4 gene. This protein is involved in the inhibition of T-cell mediated immune responses.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Cytotoxic T-lymphocyte protein 4 (223 aa, ~25 kDa) is encoded by the human CTLA4 gene. This protein is involved in the inhibition of T-cell mediated immune responses. |
|---|---|
| prefLabel | Cytotoxic T-Lymphocyte Protein 4
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| label | Cytotoxic T-Lymphocyte Protein 4
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| code | C17489
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| prefixIRI | NCIT:C17489
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| OMIM_Number | 123890
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| in_subset | |
| Display_Name | Cytotoxic T-Lymphocyte Protein 4
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| Preferred_Name | Cytotoxic T-Lymphocyte Protein 4
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| Contributing_Source | CTRP
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| Swiss_Prot | P16410
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| Legacy Concept Name | Cytotoxic_T-Lymphocyte-Associated_Protein-4
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| DesignNote | CTLA-4 is an inhibitory T-cell surface receptor for B7 ligands on antigen presenting cells that shares significant homology and ligand specificity with CD28. While CD28 is on the membrane of resting T-cells, CTLA-4 is detectable only on cells activated after antigen presentation and CTLA-4 binds to B7 with a greater affinity. B7 antigen presenting cells regulate T-cell activation by delivering stimulatory signals through CD28 and inhibitory signals through CTLA-4. A CTLA-4 splice variant with a deleted transmembrane segment (soluble CTLA-4 or sCTLA-4) is preferentially expressed in non-activated T-cells. Activation of lymphocytes results in the disappearance of sCTLA-4 followed by its gradual reappearance, whereas CTLA-4 increases after activation. (OMIM)
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| type | |
| subClassOf | |
| Semantic_Type |
Amino Acid, Peptide, or Protein
Immunologic Factor
Receptor
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| UMLS_CUI | C0111208
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