Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C174762
http://purl.obolibrary.org/obo/NCIT_C174762
Preferred Name

Zoligratinib
Definitions
An orally bioavailable inhibitor of the fibroblast growth factor receptor subtypes 1 (FGFR-1), 2 (FGFR-2) and 3 (FGFR-3), with potential antineoplastic activity. Zoligratinib binds to and inhibits FGFR-1, -2, and -3, which result in the inhibition of FGFR-mediated signal transduction pathways. This leads to the inhibition of both tumor cell proliferation and angiogenesis, and causes cell death in FGFR-overexpressing tumor cells. FGFR, a family of receptor tyrosine kinases upregulated in many tumor cell types, is essential for tumor cellular proliferation, differentiation and survival.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

An orally bioavailable inhibitor of the fibroblast growth factor receptor subtypes 1 (FGFR-1), 2 (FGFR-2) and 3 (FGFR-3), with potential antineoplastic activity. Zoligratinib binds to and inhibits FGFR-1, -2, and -3, which result in the inhibition of FGFR-mediated signal transduction pathways. This leads to the inhibition of both tumor cell proliferation and angiogenesis, and causes cell death in FGFR-overexpressing tumor cells. FGFR, a family of receptor tyrosine kinases upregulated in many tumor cell types, is essential for tumor cellular proliferation, differentiation and survival.
prefLabel
Zoligratinib
label
Zoligratinib
NCI_META_CUI
CL1412276
code
C174762
Has_Target
prefixIRI
NCIT:C174762
in_subset
Display_Name
Zoligratinib
Preferred_Name
Zoligratinib
FDA_UNII_Code
NR9ZYH80Z8
Contributing_Source
CTRP
FDA
Maps_To
FGFR Inhibitor Debio 1347
CAS_Registry
1265229-25-1
NCI_Drug_Dictionary_ID
808368
type
Is_Value_For_GDC_Property
subClassOf
Semantic_Type
Pharmacologic Substance
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