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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C174518
http://purl.obolibrary.org/obo/NCIT_C174518
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|---|---|
| Preferred Name | Maackia amurensis Seed Lectin |
| Definitions |
A preparation of lectin extracted from the seeds of Maackia amurensis, with potential antineoplastic activity. Upon administration, Maackia amurensis seed lectin (MASL) may target and bind to podoplanin (PDPN), thereby blocking the activation of PDPN by endogenous ligands. This may inhibit tumor cell growth, migration and metastasis that result from PDPN activation. PDPN, a transmembrane receptor glycoprotein that is overexpressed in some cancer types, promotes tumor cell migration, invasion, and metastasis upon activation by various endogenous ligands.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A preparation of lectin extracted from the seeds of Maackia amurensis, with potential antineoplastic activity. Upon administration, Maackia amurensis seed lectin (MASL) may target and bind to podoplanin (PDPN), thereby blocking the activation of PDPN by endogenous ligands. This may inhibit tumor cell growth, migration and metastasis that result from PDPN activation. PDPN, a transmembrane receptor glycoprotein that is overexpressed in some cancer types, promotes tumor cell migration, invasion, and metastasis upon activation by various endogenous ligands. |
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| prefLabel | Maackia amurensis Seed Lectin
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| label | Maackia amurensis Seed Lectin
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| NCI_META_CUI | CL1412017
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| PDQ_Closed_Trial_Search_ID | 802340
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| code | C174518
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| prefixIRI | NCIT:C174518
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| in_subset |
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| Display_Name | Maackia amurensis Seed Lectin
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| Preferred_Name | Maackia amurensis Seed Lectin
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| Contributing_Source | CTRP
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| Maps_To | Maackia amurensis Seed Lectin
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| NCI_Drug_Dictionary_ID | 802340
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 802340
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| Semantic_Type | Pharmacologic Substance
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