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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C174400
http://purl.obolibrary.org/obo/NCIT_C174400
|
|---|---|
| Preferred Name | MCL-1 Inhibitor ABBV-467 |
| Definitions |
An inhibitor of induced myeloid leukemia cell differentiation protein (myeloid cell leukemia-1; Mcl-1; Bcl2-L-3), with potential pro-apoptotic and antineoplastic activities. Upon administration, MCL-1 inhibitor ABBV-467 targets and binds to Mcl-1, thereby preventing the binding of Mcl-1 to and inactivation of certain pro-apoptotic proteins. This promotes apoptosis of cells overexpressing Mcl-1. Mcl-1, an anti-apoptotic protein belonging to the B-cell lymphoma 2 (Bcl-2) family of proteins, is upregulated in cancer cells and promotes tumor cell survival.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An inhibitor of induced myeloid leukemia cell differentiation protein (myeloid cell leukemia-1; Mcl-1; Bcl2-L-3), with potential pro-apoptotic and antineoplastic activities. Upon administration, MCL-1 inhibitor ABBV-467 targets and binds to Mcl-1, thereby preventing the binding of Mcl-1 to and inactivation of certain pro-apoptotic proteins. This promotes apoptosis of cells overexpressing Mcl-1. Mcl-1, an anti-apoptotic protein belonging to the B-cell lymphoma 2 (Bcl-2) family of proteins, is upregulated in cancer cells and promotes tumor cell survival. |
|---|---|
| prefLabel | MCL-1 Inhibitor ABBV-467
|
| label | MCL-1 Inhibitor ABBV-467
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| NCI_META_CUI | CL1411952
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| PDQ_Closed_Trial_Search_ID | 802326
|
| code | C174400
|
| Has_Target | |
| prefixIRI | NCIT:C174400
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| in_subset |
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| Display_Name | MCL-1 Inhibitor ABBV-467
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| Preferred_Name | MCL-1 Inhibitor ABBV-467
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| Contributing_Source | CTRP
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| Maps_To | MCL-1 Inhibitor ABBV-467
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| NCI_Drug_Dictionary_ID | 802326
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 802326
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| Semantic_Type | Pharmacologic Substance
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