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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C174208
http://purl.obolibrary.org/obo/NCIT_C174208
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|---|---|
| Preferred Name | FGFR2 Inhibitor RLY-4008 |
| Definitions |
An orally bioavailable inhibitor of the fibroblast growth factor receptor 2 (FGFR2), with potential antineoplastic activity. Upon oral administration, FGFR2 inhibitor RLY-4008 binds to and inhibits FGFR2, which results in the inhibition of FGFR2-mediated signal transduction pathways. This inhibits the proliferation of FGFR2-overexpressing tumor cells. FGFR2, a receptor tyrosine kinase upregulated in many tumor cell types, plays a key role in cellular proliferation, migration and survival.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable inhibitor of the fibroblast growth factor receptor 2 (FGFR2), with potential antineoplastic activity. Upon oral administration, FGFR2 inhibitor RLY-4008 binds to and inhibits FGFR2, which results in the inhibition of FGFR2-mediated signal transduction pathways. This inhibits the proliferation of FGFR2-overexpressing tumor cells. FGFR2, a receptor tyrosine kinase upregulated in many tumor cell types, plays a key role in cellular proliferation, migration and survival. |
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| label | FGFR2 Inhibitor RLY-4008
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| prefLabel | FGFR2 Inhibitor RLY-4008
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| in_subset |
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| Preferred_Name | FGFR2 Inhibitor RLY-4008
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| Is_Value_For_GDC_Property | |
| Display_Name | FGFR2 Inhibitor RLY-4008
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| Maps_To | FGFR2 Inhibitor RLY-4008
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| PDQ_Open_Trial_Search_ID | 803114
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| Has_Target | |
| prefixIRI | NCIT:C174208
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| NCI_Drug_Dictionary_ID | 803114
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| Contributing_Source | CTRP
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| subClassOf | |
| code | C174208
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| type | |
| PDQ_Closed_Trial_Search_ID | 803114
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| Semantic_Type | Pharmacologic Substance
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| NCI_META_CUI | CL1411775
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