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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C174039
http://purl.obolibrary.org/obo/NCIT_C174039
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|---|---|
| Preferred Name | HER2 Inhibitor DZD1516 |
| Definitions |
An orally bioavailable, blood brain barrier (BBB) penetrable inhibitor of the receptor tyrosine kinase human epidermal growth factor receptor 2 (HER2; ErbB2; HER-2), with potential antineoplastic activity. Upon oral administration, HER2 inhibitor DZD1516 selectively binds to and inhibits the activity of HER2. This prevents HER2-mediated signaling and leads to cell death in HER2-expressing tumor cells. HER2, a receptor tyrosine kinase overexpressed on a variety of tumor cell types, plays an important role in tumor cell proliferation and tumor vascularization.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable, blood brain barrier (BBB) penetrable inhibitor of the receptor tyrosine kinase human epidermal growth factor receptor 2 (HER2; ErbB2; HER-2), with potential antineoplastic activity. Upon oral administration, HER2 inhibitor DZD1516 selectively binds to and inhibits the activity of HER2. This prevents HER2-mediated signaling and leads to cell death in HER2-expressing tumor cells. HER2, a receptor tyrosine kinase overexpressed on a variety of tumor cell types, plays an important role in tumor cell proliferation and tumor vascularization. |
|---|---|
| prefLabel | HER2 Inhibitor DZD1516
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| label | HER2 Inhibitor DZD1516
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| NCI_META_CUI | CL1407916
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| PDQ_Closed_Trial_Search_ID | 802459
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| code | C174039
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| Has_Target | |
| prefixIRI | NCIT:C174039
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| in_subset |
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| Display_Name | HER2 Inhibitor DZD1516
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| Preferred_Name | HER2 Inhibitor DZD1516
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| Contributing_Source | CTRP
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| Maps_To | HER2 Inhibitor DZD1516
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| NCI_Drug_Dictionary_ID | 802459
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 802459
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| Semantic_Type | Pharmacologic Substance
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