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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C173995
http://purl.obolibrary.org/obo/NCIT_C173995
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|---|---|
| Preferred Name | KRAS G12C Inhibitor GDC-6036 |
| Definitions |
An orally available inhibitor of the oncogenic KRAS substitution mutation, G12C, with potential antineoplastic activity. Upon oral administration, KRAS G12C inhibitor GDC-6036 selectively targets the KRAS G12C mutant and inhibits KRAS G12C mutant-dependent signaling. KRAS, a member of the RAS family of oncogenes, serves an important role in cell signaling, division and differentiation. Mutations of KRAS may induce constitutive signal transduction leading to tumor cell growth, proliferation, invasion, and metastasis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally available inhibitor of the oncogenic KRAS substitution mutation, G12C, with potential antineoplastic activity. Upon oral administration, KRAS G12C inhibitor GDC-6036 selectively targets the KRAS G12C mutant and inhibits KRAS G12C mutant-dependent signaling. KRAS, a member of the RAS family of oncogenes, serves an important role in cell signaling, division and differentiation. Mutations of KRAS may induce constitutive signal transduction leading to tumor cell growth, proliferation, invasion, and metastasis. |
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| prefLabel | KRAS G12C Inhibitor GDC-6036
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| label | KRAS G12C Inhibitor GDC-6036
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| NCI_META_CUI | CL1407880
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| PDQ_Closed_Trial_Search_ID | 802450
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| code | C173995
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| Has_Target | |
| prefixIRI | NCIT:C173995
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| in_subset |
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| Display_Name | KRAS G12C Inhibitor GDC-6036
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| Preferred_Name | KRAS G12C Inhibitor GDC-6036
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| FDA_UNII_Code | E6S21PVT91
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| Contributing_Source |
CTRP
FDA
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| Maps_To | KRAS G12C Inhibitor GDC-6036
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| CAS_Registry | 2417917-17-8
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| NCI_Drug_Dictionary_ID | 802450
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 802450
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| Semantic_Type | Pharmacologic Substance
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