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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C173969
http://purl.obolibrary.org/obo/NCIT_C173969
|
|---|---|
| Preferred Name | Anti-CD25 Monoclonal Antibody RO7296682 |
| Definitions |
A monoclonal antibody against CD25 (IL-2R alpha), with potential antineoplastic activity. Upon administration, the anti-CD25 monoclonal antibody RO7296682 targets and binds to CD25 expressed on tumor-infiltrating regulatory T (Treg) cells. This may deplete Treg cells and prevent immunosuppression, thereby enhancing anti-tumor immune responses. CD25, the alpha chain of the interleukin (IL)-2 receptor, is highly expressed on Treg cells but not on effector T (Teff) cells in tumors.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A monoclonal antibody against CD25 (IL-2R alpha), with potential antineoplastic activity. Upon administration, the anti-CD25 monoclonal antibody RO7296682 targets and binds to CD25 expressed on tumor-infiltrating regulatory T (Treg) cells. This may deplete Treg cells and prevent immunosuppression, thereby enhancing anti-tumor immune responses. CD25, the alpha chain of the interleukin (IL)-2 receptor, is highly expressed on Treg cells but not on effector T (Teff) cells in tumors. |
|---|---|
| prefLabel | Anti-CD25 Monoclonal Antibody RO7296682
|
| label | Anti-CD25 Monoclonal Antibody RO7296682
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| NCI_META_CUI | CL1407855
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| PDQ_Closed_Trial_Search_ID | 802183
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| code | C173969
|
| prefixIRI | NCIT:C173969
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| in_subset |
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| Display_Name | Anti-CD25 Monoclonal Antibody RO7296682
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| Preferred_Name | Anti-CD25 Monoclonal Antibody RO7296682
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| FDA_UNII_Code | HV8TQI2IKP
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Anti-CD25 Monoclonal Antibody RO7296682
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| NCI_Drug_Dictionary_ID | 802183
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 802183
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| Semantic_Type | Pharmacologic Substance
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