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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1739
http://purl.obolibrary.org/obo/NCIT_C1739
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|---|---|
| Preferred Name | Vincristine Sulfate |
| Definitions |
The sulfate salt of a natural alkaloid isolated from the plant Catharanthus roseus (Vinca rosea L.) with antimitotic and antineoplastic activities. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca(2+)-activated ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The sulfate salt of a natural alkaloid isolated from the plant Catharanthus roseus (Vinca rosea L.) with antimitotic and antineoplastic activities. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca(2+)-activated ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. |
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| prefLabel | Vincristine Sulfate
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| label | Vincristine Sulfate
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| PDQ_Closed_Trial_Search_ID | 42251
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| code | C1739
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| Has_Target | |
| prefixIRI | NCIT:C1739
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| in_subset |
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| Display_Name | Vincristine Sulfate
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| Preferred_Name | Vincristine Sulfate
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| FDA_UNII_Code | T5IRO3534A
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C46H56N4O10.H2O4S
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| Maps_To | Vincristine Sulfate
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| CAS_Registry | 2068-78-2
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| NSC Number | 67574
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| NCI_Drug_Dictionary_ID | 42251
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| Legacy Concept Name | Vincristine_Sulfate
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| Has_Free_Acid_Or_Base_Form | |
| type | |
| ALT_DEFINITION | A drug used to treat acute leukemia. It is used in combination with other drugs to treat Hodgkin disease, non-Hodgkin lymphoma, rhabdomyosarcoma, neuroblastoma, and Wilms tumor. Oncovin is also being studied in the treatment of other types of cancer. It blocks cell growth by stopping cell division. It is a type of vinca alkaloid and a type of antimitotic agent.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 42251
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| Accepted_Therapeutic_Use_For | Acute Lymphoblastic Leukemia; Acute Myeloid Leukemia; Neuroblastoma
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0042680
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