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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C173718
http://purl.obolibrary.org/obo/NCIT_C173718
|
|---|---|
| Preferred Name | HPV6/11-targeted DNA Plasmid Vaccine INO-3107 |
| Definitions |
A DNA vaccine consisting of plasmids encoding E6 and E7 genes of human papilloma virus subtype 6 (HPV-6) and 11 (HPV-11), with potential immunostimulating and antineoplastic activities. Upon administration via intramuscular electroporation, the HPV-6/11-targeted DNA plasmid vaccine INO-3107 expresses the HPV-6/11 E6 and E7 proteins, which may elicit a cytotoxic T-lymphocyte (CTL) response against tumor cells that are expressing HPV6 and/or HPV11 E6 and E7 proteins, resulting in tumor cell lysis. HPV-6/11 infections are associated with aerodigestive malignancies.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A DNA vaccine consisting of plasmids encoding E6 and E7 genes of human papilloma virus subtype 6 (HPV-6) and 11 (HPV-11), with potential immunostimulating and antineoplastic activities. Upon administration via intramuscular electroporation, the HPV-6/11-targeted DNA plasmid vaccine INO-3107 expresses the HPV-6/11 E6 and E7 proteins, which may elicit a cytotoxic T-lymphocyte (CTL) response against tumor cells that are expressing HPV6 and/or HPV11 E6 and E7 proteins, resulting in tumor cell lysis. HPV-6/11 infections are associated with aerodigestive malignancies. |
|---|---|
| prefLabel | HPV6/11-targeted DNA Plasmid Vaccine INO-3107
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| label | HPV6/11-targeted DNA Plasmid Vaccine INO-3107
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| NCI_META_CUI | CL1407562
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| PDQ_Closed_Trial_Search_ID | 802021
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| code | C173718
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| Has_Target | |
| prefixIRI | NCIT:C173718
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| in_subset |
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| Display_Name | HPV6/11-targeted DNA Plasmid Vaccine INO-3107
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| Preferred_Name | HPV6/11-targeted DNA Plasmid Vaccine INO-3107
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| Contributing_Source | CTRP
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| Maps_To | HPV6/11-targeted DNA Plasmid Vaccine INO-3107
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| NCI_Drug_Dictionary_ID | 802021
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 802021
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| Semantic_Type | Pharmacologic Substance
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