Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C173701
http://purl.obolibrary.org/obo/NCIT_C173701
|
|---|---|
| Preferred Name | Ginisortamab |
| Definitions |
A monoclonal antibody directed against gremlin-1 (GREM1; Drm), with potential antineoplastic activity. Upon administration,ginisortamab specifically targets and binds to gremlin-1, thereby neutralizing Gremlin-1. This may block the gremlin-1-mediated inhibition of bone morphogenetic protein (BMP) signaling pathways, and may lead to the inhibition of tumor cell growth and proliferation. Gremlin-1, a BMP antagonist that is overexpressed in a variety of cancer cell types, is involved in cancer cell growth and proliferation as well as tissue fibrosis.
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A monoclonal antibody directed against gremlin-1 (GREM1; Drm), with potential antineoplastic activity. Upon administration,ginisortamab specifically targets and binds to gremlin-1, thereby neutralizing Gremlin-1. This may block the gremlin-1-mediated inhibition of bone morphogenetic protein (BMP) signaling pathways, and may lead to the inhibition of tumor cell growth and proliferation. Gremlin-1, a BMP antagonist that is overexpressed in a variety of cancer cell types, is involved in cancer cell growth and proliferation as well as tissue fibrosis. |
|---|---|
| prefLabel | Ginisortamab
|
| label | Ginisortamab
|
| NCI_META_CUI | CL1407518
|
| PDQ_Closed_Trial_Search_ID | 802055
|
| code | C173701
|
| prefixIRI | NCIT:C173701
|
| in_subset |
See more
See less
|
| Display_Name | Ginisortamab
|
| Preferred_Name | Ginisortamab
|
| FDA_UNII_Code | 6808SG2XRK
|
| Contributing_Source |
CTRP
FDA
|
| Maps_To | Anti-gremlin-1 Monoclonal Antibody UCB6114
|
| CAS_Registry | 2390147-17-6
|
| NCI_Drug_Dictionary_ID | 802055
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 802055
|
| Semantic_Type | Pharmacologic Substance
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |