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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C173550
http://purl.obolibrary.org/obo/NCIT_C173550
|
|---|---|
| Preferred Name | Hsp90 Inhibitor TQB3474 |
| Definitions |
An inhibitor of heat shock protein 90 (Hsp90), with potential antineoplastic activity. Upon administration, Hsp90 inhibitor TQB3474 specifically blocks Hsp90, which inhibits its chaperone function and promotes the proteasomal degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival. This may lead to an inhibition of tumor cell proliferation. Hsp90, a chaperone complex protein upregulated in a variety of tumor cell types, regulates the folding and degradation of many oncogenic signaling proteins.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An inhibitor of heat shock protein 90 (Hsp90), with potential antineoplastic activity. Upon administration, Hsp90 inhibitor TQB3474 specifically blocks Hsp90, which inhibits its chaperone function and promotes the proteasomal degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival. This may lead to an inhibition of tumor cell proliferation. Hsp90, a chaperone complex protein upregulated in a variety of tumor cell types, regulates the folding and degradation of many oncogenic signaling proteins. |
|---|---|
| prefLabel | Hsp90 Inhibitor TQB3474
|
| label | Hsp90 Inhibitor TQB3474
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| NCI_META_CUI | CL1407320
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| PDQ_Closed_Trial_Search_ID | 801900
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| code | C173550
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| prefixIRI | NCIT:C173550
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| in_subset | |
| Preferred_Name | Hsp90 Inhibitor TQB3474
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| Maps_To | Hsp90 Inhibitor TQB3474
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| NCI_Drug_Dictionary_ID | 801900
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 801900
|
| Semantic_Type | Pharmacologic Substance
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